Synthesis of α-aminophosphonates by the Kabachnik–Fields reaction and by the Pudovik reaction

Bálint, Erika and Tripolszky, Anna and Tajti, Ádám (2018) Synthesis of α-aminophosphonates by the Kabachnik–Fields reaction and by the Pudovik reaction. In: Organophosphorus Chemistry - Novel Developments. Walter de Gruyter GmbH, Berlin, pp. 108-147. ISBN 978-3-11-053583-9

Preview

Text EB AT AT Ch 6.pdf Download (408kB) | Preview

Abstract

α-Aminophosphonates are of significant importance due to their biological activity. The most widely applied synthetic routes towards α-aminophosphonates are the Kabachnik-Fields reaction involving the condensation of amines, oxo compounds and >P(O)H species, such as dialkyl phosphites, and the Pudovik reaction of imines and >P(O)H reagents. By the double Kabachnik-Fields reaction, bis(aminophosphonates) have also became available. This chapter summarizes the synthesis of α-aminophosphonates and related derivatives through the two main routes as described in the literature over the last five years.

Actions (login required)

Edit Item