Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging

Khairnar, Amit and Ruda-Kucerova, Jana and Drazanova, Eva and Szabó, Nikoletta and Latta, Peter and Arab, Anas and Hutter-Paier, Brigit and Havas, Daniel and Windisch, Manfred and Sulcova, Alexandra and Starzuk Jr, Zenon and Király, András and Rektorova, Irena (2016) Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging. Journal of Neurochemistry, 136 (61259). pp. 1259-1269. ISSN 0022-3042 (print), 1471-4159 (online)

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Abstract

Diffusion kurtosis imaging (DKI) by measuring non-Gaussian diffusion allows the accurate estimation of the distribution of water molecule displacement and may correctly characterize microstructural brain changes caused by neurodegeneration. The aim of the present study was to evaluate the ability of DKI to detect changes induced by α-synuclein (α-Syn) accumulation in both gray matter (GM) and white matter (WM) in α-Syn overexpressing transgenic mice (TNWT-61). The study provides evidence of an association between the amount of α-Syn and the magnitude of DKI metric changes in the ROIs, with the potential of improving the clinical diagnosis of PD.

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