Kócsó, Dániel J. and Szabó-Fodor, Judit and Mézes, Miklós and Balogh, Krisztián and Ferenczi, Szilamér and Szabó, András and Bóta, Brigitta and Kovács, Melinda (2018) Fumonisin B1 exposure increases Hsp70 expression in the lung and kidney of rats without inducing significant oxidative stress. Acta Veterinaria Hungarica, 66 (3). pp. 394-407. ISSN 0236-6290
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Abstract
The objective of this experiment was to determine whether fumonisin B<sub>1</sub> (FB<sub>1</sub>) added to the diet of rats in a dose of 50 mg/kg changes the production of heat shock protein 70 (Hsp70) in the lungs and kidney of rats. We also studied the effect of this mycotoxin on the antioxidant system of the body. Mature (8 weeks old) male Wistar Crl:WI BR rats (n = 6/group) were fed the toxin-containing diet for 5 days. FB1 resulted in a 7% body weight reduction without significantly changing the feed intake. Western blot analysis of the lungs and kidney demonstrated a substantial (1.4-fold and 1.8-fold, respectively) increase in Hsp70 expression. Alterations could not be detected in the clinical chemical parameters (total protein, albumin, total cholesterol, glucose, creatinine and urea concentrations, and aspartate aminotransferase activity). There was no statistically significant change in malondialdehyde concentrations and the measured antioxidant parameters (the amount of reduced glutathione, GSH and glutathione peroxidase activity, GPx) in the blood plasma, lung and kidney tissue. Thus, it can be concluded that FB<sub>1</sub> did not induce oxidative stress in the lungs and kidney, but increased Hsp70 production.
Item Type: | Article |
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Subjects: | S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány |
Depositing User: | Erika Bilicsi |
Date Deposited: | 02 Oct 2018 06:24 |
Last Modified: | 30 Sep 2019 23:16 |
URI: | http://real.mtak.hu/id/eprint/86492 |
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