Influence of pressure on the retention of resorcinarene-based cavitands

Prauda, Ibolya and Bartó, Endre and Felinger, Attila (2018) Influence of pressure on the retention of resorcinarene-based cavitands. JOURNAL OF CHROMATOGRAPHY A, 1535. pp. 123-128. ISSN 0021-9673

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Abstract

The thermodynamics of the retention mechanism of resorcinarene-based cavitands in RPLC as well asthe nature of the binding sites have been studied recently. In the present study, the influence of pressureon the retention of the cyclic tetramers on alkylsilyl and polar-embedded C8and C18stationary phases isinvestigated using aqueous methanol mobile phase. The pressure effect for cavity-shaped molecules hasbeen scarcely studied so far. We observed that the retention factors of the analytes increased with theincrease of the average column pressure (1–400 bar) when using restricting capillary tubes. The calculatedmolar volume changes were negative, between −�Vm= 5–19 mL/mol on all types of stationary phases.Comparing the different stationary phases, we found that the molar volume changes for both the apolarand more polar analytes were twice larger on the Hypersil BDS (base deactivated silica) than on theXTerra columns and they were independent of the length of the alkyl chains of the stationary phases.

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