Transcriptome evolution from breast epithelial cells to basallike tumors

Santpere, G. and Alcaráz-Sanabria, A. and Corrales-Sanchez, V. and Pandiella, A. and Győrffy, Balázs (2018) Transcriptome evolution from breast epithelial cells to basallike tumors. Oncotarget, 9 (1). pp. 453-463. ISSN 1949-2553


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In breast cancer, it is unclear the functional modifications at a transcriptomic level that are associated with the evolution from epithelial cells and ductal carcinoma in situ (DCIS) to basal-like tumors. By applying weighted gene co-expression network analysis (WGCNA), we identified 17 gene co-expression modules in normal, DCIS and basal-like tumor samples. We then correlated the expression pattern of these gene modules with disease progression from normal to basal-like tumours and found eight modules exhibiting a high and statistically significant correlation. M4 included genes mainly related to cell cycle/division and DNA replication like CCNA2 or CDK1. The M7 module included genes linked with the immune response showing top hub genes such as CD86 or PTPRC. M10 was found specifically correlated to DCIS, but not to basal-like tumor samples, and showed enrichment in ubiquitination or ubiquitin-like processes. We observed that genes in some of these modules were associated with clinical outcome and/or represented druggable opportunities, including AURKA, AURKB, PLK1, MCM2, CDK1, YWHAE, HSP90AB1, LCK, or those targeting ubiquitination. In conclusion, we describe relevant gene modules related to biological functions that can influence survival and be targeted pharmacologically. © Santpere et al.

Item Type: Article
Uncontrolled Keywords: GENE; ARTICLE; human; Cell Division; genetic analysis; controlled study; Cell Cycle; Gene Expression; DNA Replication; human cell; human tissue; immune response; UBIQUITIN; breast cancer; cancer growth; gene identification; transcriptomics; molecular evolution; basal cell carcinoma; CD86 antigen; gene function; intraductal carcinoma; carcinoma in situ; Transcriptome; Clinical outcome; protein kinase Lck; cyclin dependent kinase 1; Ubiquitination; epidermal growth factor receptor 4; aurora B kinase; aurora A kinase; polo like kinase 1; PYRIN; CD86 gene; TPX2 gene; AURKA gene; cyclin A2; EBF1 gene; CDK1 gene; minichromosome maintenance protein 2; LEP gene; AGR2 gene; HLA C gene; YWHAE gene; weighted gene co expression network analysis; UBE2T gene; UBE2G1 gene; TUSC5 gene; TUBB gene; TOMM20 gene; TMEM251 gene; TFEC gene; TCF4 gene; STAT1 gene; STARD9 gene; SSB gene; SPDEF gene; SMIM15 gene; SLC25A39 gene; SCN3B gene; SAMSN1 gene; RPS7 gene; RNF111 gene; RAB27B gene; PTPRC gene; PPP2R1A gene; PLK1 gene; PGM5P2 gene; PFN1 gene; PCNA gene; PCK1 gene; OPHN1 gene; OLFML1 gene; NRBF2 gene; MRGPRF gene; MLPH gene; MEOX2 gene; MEG3 gene; MEFV gene; MCM2 gene; MAD2L1 gene; LCK gene; KLHDC3 gene; ISG15 gene; HSP90AB1 gene; HDC gene; GPD1 gene; GNG11 gene; FYB gene; FRG1B gene; FOXA1 gene; FAM179B gene; ERI3 gene; ERBB4 gene; DMXL1 gene; CIDEC gene; CHMP2B gene; CETN3 gene; CCNA2 gene; CCDC144CP gene; CAV1 gene; breast epithelium cell; AURKB gene; ATP8B1 gene; ARRB2 gene; ANKRD30A gene; ALDOC gene; AKAP12 gene; ACSM2A gene; voltage gated sodium channel beta 3 subunit; hepatocyte nuclear factor 3alpha; Transcriptomic evolution;
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Depositing User: MTMT SWORD
Date Deposited: 05 Mar 2019 13:12
Last Modified: 05 Mar 2019 13:12

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