TMCrys: predict propensity of success for transmembrane protein crystallization

Varga, Julia Kornélia and Tusnády, Gábor (2018) TMCrys: predict propensity of success for transmembrane protein crystallization. BIOINFORMATICS, 34 (18). pp. 3126-3130. ISSN 1367-4803

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Abstract

Motivation Transmembrane proteins (TMPs) are crucial in the life of the cells. As they have special properties, their structure is hard to determine––the PDB database consists of 2% TMPs, despite the fact that they are predicted to make up to 25% of the human proteome. Crystallization prediction methods were developed to aid the target selection for structure determination, however, there is a need for a TMP specific service. Results Here, we present TMCrys, a crystallization prediction method that surpasses existing prediction methods in performance thanks to its specialization for TMPs. We expect TMCrys to improve target selection of TMPs.

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