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Protein Phase Separation: A New Phase in Cell Biology

Boeynaems, Steven and Alberti, Simon and Fawzi, Nicolas L. and Mittag, Tanja and Polymenidou, Magdalini and Rousseau, Frederic and Schymkowitz, Joost and Shorter, James and Wolozin, Benjamin and Van Den Bosch, Ludo and Tompa, Péter and Fuxreiter, Mónika (2018) Protein Phase Separation: A New Phase in Cell Biology. TRENDS IN CELL BIOLOGY, 28 (6). pp. 420-435. ISSN 0962-8924

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Abstract

Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, formation, regulation, and function of membraneless organelles. A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders. © 2018

Item Type: Article
Additional Information: Megjegyzés-27441855 N1 Funding details: C1, KU Leuven N1 Funding details: 647458, H2020, Horizon 2020 Framework Programme N1 Funding details: G.0029.12, EMBO N1 Funding details: R01GM118530 N1 Funding details: ERC, European Research Council N1 Funding details: ASRF, Applied Scientific Research Fund N1 Funding details: MTA, Magyar Tudományos Akadémia N1 Funding details: GINOP-2.3.2-15-2016-00044 N1 Funding text: This manuscript is based on discussions held at the Phase Transitions in Biology and Disease meeting held in Leuven, May 2nd–3th, 2017, and the seminal discoveries of Dr Anthony A. Hyman, Dr Michael K. Rosen, and others. The authors would like to thank Dr Roy Parker, Dr J. Paul Taylor, Dr Clifford Brangwynne, and Dr Steve McKnight for helpful discussions during the preparation of this manuscript. The authors would like to thank Dr Alex Holehouse and Dr Rohit V. Pappu for contributing text and providing helpful comments. The two anonymous reviewers are gratefully acknowledged for their thorough review and critique of the manuscript. M.F. acknowledges financial support of GINOP-2.3.2-15-2016-00044 , and the Hungarian Academy of Sciences . S.B and L.V.D.B are supported by KU Leuven (‘Opening the future’ and C1), the Fund for Scientific Research Flanders (FWO-Vlaanderen), the ‘Agency for Innovation by Science and Technology in Flanders’ (IWT-Vlaanderen) and the ALS Liga (Belgium). S.B. acknowledges a long-term fellowship from EMBO. P.T. is supported by Odysseus grant G.0029.12 from FWO-Vlaanderen . J.S. is supported by a grant from the European Research Council under the European Union’s Horizon 2020 Framework Programme ERC Grant agreement 647458 (MANGO). N.L.F. acknowledges support by NIGMS R01GM118530 . Megjegyzés-27444346 N1 Funding details: C1, KU Leuven N1 Funding details: 647458, H2020, Horizon 2020 Framework Programme N1 Funding details: G.0029.12, EMBO N1 Funding details: R01GM118530 N1 Funding details: ERC, European Research Council N1 Funding details: ASRF, Applied Scientific Research Fund N1 Funding details: MTA, Magyar Tudományos Akadémia N1 Funding details: GINOP-2.3.2-15-2016-00044 N1 Funding text: This manuscript is based on discussions held at the Phase Transitions in Biology and Disease meeting held in Leuven, May 2nd–3th, 2017, and the seminal discoveries of Dr Anthony A. Hyman, Dr Michael K. Rosen, and others. The authors would like to thank Dr Roy Parker, Dr J. Paul Taylor, Dr Clifford Brangwynne, and Dr Steve McKnight for helpful discussions during the preparation of this manuscript. The authors would like to thank Dr Alex Holehouse and Dr Rohit V. Pappu for contributing text and providing helpful comments. The two anonymous reviewers are gratefully acknowledged for their thorough review and critique of the manuscript. M.F. acknowledges financial support of GINOP-2.3.2-15-2016-00044 , and the Hungarian Academy of Sciences . S.B and L.V.D.B are supported by KU Leuven (‘Opening the future’ and C1), the Fund for Scientific Research Flanders (FWO-Vlaanderen), the ‘Agency for Innovation by Science and Technology in Flanders’ (IWT-Vlaanderen) and the ALS Liga (Belgium). S.B. acknowledges a long-term fellowship from EMBO. P.T. is supported by Odysseus grant G.0029.12 from FWO-Vlaanderen . J.S. is supported by a grant from the European Research Council under the European Union’s Horizon 2020 Framework Programme ERC Grant agreement 647458 (MANGO). N.L.F. acknowledges support by NIGMS R01GM118530 . Megjegyzés-27445675 N1 Funding details: C1, KU Leuven N1 Funding details: 647458, H2020, Horizon 2020 Framework Programme N1 Funding details: G.0029.12, EMBO N1 Funding details: R01GM118530 N1 Funding details: ERC, European Research Council N1 Funding details: ASRF, Applied Scientific Research Fund N1 Funding details: MTA, Magyar Tudományos Akadémia N1 Funding details: GINOP-2.3.2-15-2016-00044 N1 Funding text: This manuscript is based on discussions held at the Phase Transitions in Biology and Disease meeting held in Leuven, May 2nd–3th, 2017, and the seminal discoveries of Dr Anthony A. Hyman, Dr Michael K. Rosen, and others. The authors would like to thank Dr Roy Parker, Dr J. Paul Taylor, Dr Clifford Brangwynne, and Dr Steve McKnight for helpful discussions during the preparation of this manuscript. The authors would like to thank Dr Alex Holehouse and Dr Rohit V. Pappu for contributing text and providing helpful comments. The two anonymous reviewers are gratefully acknowledged for their thorough review and critique of the manuscript. M.F. acknowledges financial support of GINOP-2.3.2-15-2016-00044 , and the Hungarian Academy of Sciences . S.B and L.V.D.B are supported by KU Leuven (‘Opening the future’ and C1), the Fund for Scientific Research Flanders (FWO-Vlaanderen), the ‘Agency for Innovation by Science and Technology in Flanders’ (IWT-Vlaanderen) and the ALS Liga (Belgium). S.B. acknowledges a long-term fellowship from EMBO. P.T. is supported by Odysseus grant G.0029.12 from FWO-Vlaanderen . J.S. is supported by a grant from the European Research Council under the European Union’s Horizon 2020 Framework Programme ERC Grant agreement 647458 (MANGO). N.L.F. acknowledges support by NIGMS R01GM118530 . Megjegyzés-27448538 N1 Funding details: C1, KU Leuven N1 Funding details: 647458, H2020, Horizon 2020 Framework Programme N1 Funding details: G.0029.12, EMBO N1 Funding details: R01GM118530 N1 Funding details: ERC, European Research Council N1 Funding details: ASRF, Applied Scientific Research Fund N1 Funding details: MTA, Magyar Tudományos Akadémia N1 Funding details: GINOP-2.3.2-15-2016-00044 N1 Funding text: This manuscript is based on discussions held at the Phase Transitions in Biology and Disease meeting held in Leuven, May 2nd–3th, 2017, and the seminal discoveries of Dr Anthony A. Hyman, Dr Michael K. Rosen, and others. The authors would like to thank Dr Roy Parker, Dr J. Paul Taylor, Dr Clifford Brangwynne, and Dr Steve McKnight for helpful discussions during the preparation of this manuscript. The authors would like to thank Dr Alex Holehouse and Dr Rohit V. Pappu for contributing text and providing helpful comments. The two anonymous reviewers are gratefully acknowledged for their thorough review and critique of the manuscript. M.F. acknowledges financial support of GINOP-2.3.2-15-2016-00044 , and the Hungarian Academy of Sciences . S.B and L.V.D.B are supported by KU Leuven (‘Opening the future’ and C1), the Fund for Scientific Research Flanders (FWO-Vlaanderen), the ‘Agency for Innovation by Science and Technology in Flanders’ (IWT-Vlaanderen) and the ALS Liga (Belgium). S.B. acknowledges a long-term fellowship from EMBO. P.T. is supported by Odysseus grant G.0029.12 from FWO-Vlaanderen . J.S. is supported by a grant from the European Research Council under the European Union’s Horizon 2020 Framework Programme ERC Grant agreement 647458 (MANGO). N.L.F. acknowledges support by NIGMS R01GM118530 . Department of Genetics, Stanford University School of Medicine, Stanford, CA, United States KU Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, Belgium Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, United States Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland Switch Laboratory, VIB, Leuven, Belgium KU Leuven, Department for Cellular and Molecular Medicine, Leuven, Belgium Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States Department of Pharmacology, Boston University School of Medicine, Boston, MA, United States Department of Neurology, Boston University School of Medicine, Boston, MA, United States VIB, Center for Structural Biology (CSB), Vrije Universiteit Brussel (VUB), Brussels, Belgium Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary MTA-DE Laboratory of Protein Dynamics, Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary Cited By :32 Export Date: 9 January 2019 CODEN: TCBIE Correspondence Address: Boeynaems, S.; VIB, Center for Brain and Disease Research, Laboratory of NeurobiologyBelgium; email: sboeynae@stanford.edu Chemicals/CAS: protein, 67254-75-5 Funding details: KU Leuven, C1 Funding details: Horizon 2020 Framework Programme, H2020, 647458 Funding details: EMBO, G.0029.12 Funding details: R01GM118530 Funding details: European Research Council, ERC Funding details: Applied Scientific Research Fund, ASRF Funding details: Magyar Tudományos Akadémia, MTA Funding details: GINOP-2.3.2-15-2016-00044 Funding text 1: This manuscript is based on discussions held at the Phase Transitions in Biology and Disease meeting held in Leuven, May 2nd–3th, 2017, and the seminal discoveries of Dr Anthony A. Hyman, Dr Michael K. Rosen, and others. The authors would like to thank Dr Roy Parker, Dr J. Paul Taylor, Dr Clifford Brangwynne, and Dr Steve McKnight for helpful discussions during the preparation of this manuscript. The authors would like to thank Dr Alex Holehouse and Dr Rohit V. Pappu for contributing text and providing helpful comments. The two anonymous reviewers are gratefully acknowledged for their thorough review and critique of the manuscript. M.F. acknowledges financial support of GINOP-2.3.2-15-2016-00044 , and the Hungarian Academy of Sciences . S.B and L.V.D.B are supported by KU Leuven (‘Opening the future’ and C1), the Fund for Scientific Research Flanders (FWO-Vlaanderen), the ‘Agency for Innovation by Science and Technology in Flanders’ (IWT-Vlaanderen) and the ALS Liga (Belgium). S.B. acknowledges a long-term fellowship from EMBO. P.T. is supported by Odysseus grant G.0029.12 from FWO-Vlaanderen . J.S. is supported by a grant from the European Research Council under the European Union’s Horizon 2020 Framework Programme ERC Grant agreement 647458 (MANGO). N.L.F. acknowledges support by NIGMS R01GM118530 . Funding Agency and Grant Number: Hungarian Academy of Sciences; KU Leuven; Fund for Scientific Research Flanders (FWO-Vlaanderen); 'Agency for Innovation by Science and Technology in Flanders' (IWT-Vlaanderen); ALS Liga (Belgium); EMBO; Odysseus grant from FWO-Vlaanderen [G.0029.12]; European Research Council under the European Union's Horizon Framework Programme ERC [647458]; NIGMS [R01GM118530]; [GINOP-2.3.2-15-2016-00044] Funding text: This manuscript is based on discussions held at the Phase Transitions in Biology and Disease meeting held in Leuven, May 2nd-3th, 2017, and the seminal discoveries of Dr Anthony A. Hyman, Dr Michael K. Rosen, and others. The authors would like to thank Dr Roy Parker, Dr J. Paul Taylor, Dr Clifford Brangwynne, and Dr Steve McKnight for helpful discussions during the preparation of this manuscript. The authors would like to thank Dr Alex Holehouse and Dr Rohit V. Pappu for contributing text and providing helpful comments. The two anonymous reviewers are gratefully acknowledged for their thorough review and critique of the manuscript. M.F. acknowledges financial support of GINOP-2.3.2-15-2016-00044, and the Hungarian Academy of Sciences. S.B and L.V.D.B are supported by KU Leuven ('Opening the future' and C1), the Fund for Scientific Research Flanders (FWO-Vlaanderen), the 'Agency for Innovation by Science and Technology in Flanders' (IWT-Vlaanderen) and the ALS Liga (Belgium). S.B. acknowledges a long-term fellowship from EMBO. P.T. is supported by Odysseus grant G.0029.12 from FWO-Vlaanderen. J.S. is supported by a grant from the European Research Council under the European Union's Horizon 2020 Framework Programme ERC Grant agreement 647458 (MANGO). N.L.F. acknowledges support by NIGMS R01GM118530.
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 07 Mar 2019 13:54
Last Modified: 30 Jun 2019 23:17
URI: http://real.mtak.hu/id/eprint/91937

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