Varga, Zoltán and Wacha, András and Bóta, Attila (2014) Osmotic shrinkage of sterically stabilized liposomes as revealed by time-resolved small-angle X-ray scattering. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 47. pp. 35-40. ISSN 0021-8898
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Abstract
Time-resolved synchrotron small-angle X-ray scattering (SAXS) was used to study the structural changes during the osmotic shrinkage of a pharmacologi- cally relevant liposomal drug delivery system. Sterically stabilized liposomes (SSLs) with a diameter of 100nm and composed of hydrogenated soy phosphocholine, cholesterol and distearoyl-phosphoethanolamine-PEG 2000 prepared in a salt-free buffer were mixed with a buffered 0.3 M NaCl solution using a stopped flow apparatus. The changes in the liposome size and the bilayer structure were followed by using SAXS with a time resolution of 20 ms. A linear decrease in liposome size is observed during the first
| Item Type: | Article |
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| Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD02 Physical chemistry / fizikai kémia |
| Depositing User: | Dr Zoltán Varga |
| Date Deposited: | 04 Feb 2014 14:50 |
| Last Modified: | 04 Feb 2014 14:50 |
| URI: | http://real.mtak.hu/id/eprint/9718 |
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