Wintgens, V. and Guigner, J.-M. and Miskolczy, Zsombor and Amiel, C. and Biczók, László (2019) 4-Sulfonatocalixarene-induced nanoparticle formation of methylimidazolium-conjugated dextrans: Utilization for drug encapsulation. CARBOHYDRATE POLYMERS, 223. ISSN 0144-8617
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Abstract
Methylimidazolium side groups were grafted via ether linkage to dextran and the self-assembly of these polymers with 4-sulfonato-calix[n]arenes (SCXn) was studied in aqueous solutions. Dynamic light scattering and zeta potential measurements revealed the mixing ratio ranges of the constituents where stable nanoparticles could be created. The macrocycle size of SCXn and the molecular mass of the polymer barely affected the nanoparticle diameter, but the lowering of the imidazolium degree of substitution substantially diminished the stability of the associates. The pH change from neutral to acidic also unfavourably influenced the self-organization owing mainly to the decrease of the SCXn charge. Cryogenic transmission electron microscopy images proved the spherical morphology of the nanoproducts in which the stoichiometry of the constituents was always close to the one corresponding to charge compensation. The flexible and positively charged dextran-chains are compacted by the polyanionic SCXn. Coralyne, a pharmacologically important alkaloid was efficiently embedded by self-assembly in the produced nanoparticles reaching 99% association efficiency. © 2019 Elsevier Ltd
| Item Type: | Article |
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| Additional Information: | Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, Thiais, 94320, France Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie, IMPMC, Sorbonne Université, IRD, CNRS UMR 7590, MNHN, 4 Place Jussieu, Paris, 75005, France Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, P.O. Box 286, Budapest, 1519, Hungary Export Date: 3 August 2019 CODEN: CAPOD Correspondence Address: Biczók, L.; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, P.O. Box 286, Hungary; email: biczok.laszlo@ttk.mta.hu Funding Agency and Grant Number: BIONANO project [GINOP-2.3.2-15-2016-00017]; National Research, Development and Innovation Office Hungary Grant [K123995] Funding text: This work was supported by the BIONANO GINOP-2.3.2-15-2016-00017 project and the National Research, Development and Innovation Office Hungary Grant K123995 to ZM and LB. |
| Uncontrolled Keywords: | METABOLITES; ALKALOIDS; NANOPARTICLES; light scattering; Drug delivery; Drug delivery; MACROCYCLES; self-assembly; MACROCYCLE; dextran; Cryogenic transmission electron microscopy; Self assembly; alkaloid; High resolution transmission electron microscopy; nanoparticle formation; degree of substitution; Cationic polymer; Cationic polymers; Association efficiency; Spherical morphologies; Zeta potential measurements; |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 07 Sep 2019 04:11 |
| Last Modified: | 13 Jul 2020 23:15 |
| URI: | http://real.mtak.hu/id/eprint/98842 |
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