The Synthesis of N,N-Bis(dialkoxyphosphinoylmethyl)- and N,N-Bis(diphenylphosphinoylmethyl) glycine Esters by the Microwave-Assisted Double Kabachnik-Fields Reaction

Bálint, Erika and Fazekas, Eszter and Drahos, László and Keglevich, György (2013) The Synthesis of N,N-Bis(dialkoxyphosphinoylmethyl)- and N,N-Bis(diphenylphosphinoylmethyl) glycine Esters by the Microwave-Assisted Double Kabachnik-Fields Reaction. HETEROATOM CHEMISTRY, 24 (6). pp. 510-515. ISSN 1042-7163

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Abstract

The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha-Mannich) products under microwave (MW) conditions at 100 degrees C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent-free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency. (C) 2013 Wiley Periodicals, Inc.

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