Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels

Pozsgai, Gábor and Bátai, István Zoárd and Pintér, Erika (2019) Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels. BRITISH JOURNAL OF PHARMACOLOGY, 176 (4). pp. 628-645. ISSN 0007-1188 (print); 1476-5381 (online)

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Abstract

Hydrogen sulfide (H2 S) is a gaseous mediator in various physiological and pathological processes, including neuro-immune-modulation, metabolic pathways, cardiovascular system, tumour growth, inflammation and pain etc. Nowadays hydrogen polysulfides (H2 Sn ) have turned up as signalling molecules modulating ion channels, transcription factors and protein kinases. Transient Receptor Potential (TRP) cation channels can be activated by mechanical, thermal or chemical triggers. Here, we review the current literature regarding biological actions of sulfide and polysulfide compounds mediated by TRP-s with special emphasis on the role of TRPA1. Notwithstanding, TRPA1 is a best-known ion channel in nociceptors. Considering its regulatory role, it should not be forgotten about the function of non-neuronal receptors. Although, previous papers have particularly demonstrated sulfide and polysulfide effects in different pathological circumstances and TRPA1-mediated processes have also been investigated intensively, our review attempts to present the first comprehensive overview about potential cross-talk between TRPA1 and sulfide-activated signalling pathways.

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