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Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

Manczinger, Máté and Boross, Gábor and Kemény, Lajos and Müller, Viktor and Lenz, Tobias L. and Papp, Balázs and Pál, Csaba (2019) Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLOS BIOLOGY, 17 (1). ISSN 1544-9173

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Abstract

Whereas specialist major histocompatibility complex (MHC) molecules initiate immune response against only relatively few pathogens, generalists provide protection against a broad range. Accordingly, this study shows that the geographical distribution of generalist MHC alleles in human populations reflects exposure to diverse infectious diseases.

Item Type: Article
Additional Information: Funding Agency and Grant Number: "Frontline" Research Excellence Programme of the National Research, Development and Innovation Office, Hungary [KKP_ 17]; "Lendulet" Programme of the Hungarian Academy of Sciences; Wellcome Trust [GINOP-2.3.2-15-2016-00014, GINOP-2.3.2-15-2016-00020, GINOP-2.3.3-15-2016-00001, GINOP-2.3.2-15-2016-00057]; German Research Foundation [LE 2593/3-1]; New National Excellence Program of the Ministry of Human Capacities [UNKP-18-4]; Bolyai Janos Research Fellowship of the Hungarian Academy of Sciences; ELTE Institutional Excellence Program - Hungarian Ministry of Human Capacities [1783-3/2018/FEKUTSRAT] Funding text: The authors acknowledge the following financial support: "Frontline" Research Excellence Programme of the National Research, Development and Innovation Office, Hungary (KKP_ 17), "Lendulet" Programme of the Hungarian Academy of Sciences and The Wellcome Trust (BP and CP), H2020 ERC-2014-CoG (CP), GINOP-2.3.2-15-2016-00014 (EVOMER, BP and CP), GINOP-2.3.2-15-2016-00020 (MolMedEx TUMORDNS, CP), GINOP-2.3.3-15-2016-00001 (CP), GINOP-2.3.2-15-2016-00057 ("Az evolucio fenyeben: elvek es megoldasok," VM), and German Research Foundation grant LE 2593/3-1 (TLL). MM was supported by the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities, MM and VM were supported by the Bolyai Janos Research Fellowship of the Hungarian Academy of Sciences, and VM was supported in the frame of the ELTE Institutional Excellence Program (1783-3/2018/FEKUTSRAT) funded by the Hungarian Ministry of Human Capacities. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 23 Nov 2019 03:17
Last Modified: 23 Nov 2019 03:17
URI: http://real.mtak.hu/id/eprint/103639

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