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Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

Manczinger, Máté and Boross, Gábor and Kemény, Lajos and Müller, Viktor and Lenz, Tobias L. and Papp, Balázs and Pál, Csaba (2019) Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLOS BIOLOGY, 17 (1). ISSN 1544-9173

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Abstract

Whereas specialist major histocompatibility complex (MHC) molecules initiate immune response against only relatively few pathogens, generalists provide protection against a broad range. Accordingly, this study shows that the geographical distribution of generalist MHC alleles in human populations reflects exposure to diverse infectious diseases.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 23 Nov 2019 03:17
Last Modified: 20 Apr 2023 11:57
URI: http://real.mtak.hu/id/eprint/103639

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