Gels and liposomes in optimized ocular drug delivery: Studies on ciprofloxacin formulations

Budai, Lívia and Hajdú, Mária and Budai, Marianna and Gróf, Pál and Béni, Szabolcs and Noszál, Béla and Klebovich, Imre and Antal, István (2007) Gels and liposomes in optimized ocular drug delivery: Studies on ciprofloxacin formulations. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 343 (1-2). pp. 34-40. ISSN 0378-5173

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Abstract

Ciprofloxacin (CPFX) containing therapeutic systems were developed using gel- and liposome-based formulations to minimize tear-driven dilution in the conjunctival sac, a long-pursued objective in ophthalmology. Physicochemical properties (pH, osmolarity, viscosity, expansivity, membrane fluidity and in vitro CPFX release rate) of the preparations were studied by the appropriate methods. For gel preparation, the bioadhesive poly(vinyl alcohol) and polymethacrylic acid derivatives were applied in various concentrations. In our liposome-supported carrier systems, multilamellar vesicles from lecithin and alfa-l-dipalmithoyl-phosphatidylcholine provided the encapsulating agent. Electron paramagnetic resonance (EPR) spectroscopy was applied to study the molecular interactions in the ophthalmic formulations. The polymer hydrogels used in our preparations ensured a steady and prolonged active ingredient release. In addition, encapsulation of the CPFX into liposomes prolonged the in vitro release of the antibacterial agent depending on the lipid composition of the vesicles.

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