Synthesis of Carbocyclic and Heterocyclic β‑Aminocarboxylic Acids

Kiss, Lorand and Fülöp, Ferenc (2014) Synthesis of Carbocyclic and Heterocyclic β‑Aminocarboxylic Acids. Chemical Review, 114. pp. 1116-1169.


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In consequence of their biological e ff ects, conformationally constrained carbocyclic β -amino acids have generated great interest among synthetic and medicinal chemists in the past 2 decades, and they have become a hot topic in organic and bioorganic chemistry. These compounds are found in natural products and antibiotics. They are also considered important precursors for pharmacologically interesting β -lactams and other bioactive compounds. Certain carbocyclic β -amino acids, e.g., cispentacin , icofungipen , and BAY Y9379 , possess noteworthy antifungal or antibacterial activities, while tilidin , a phenyl-substituted cyclohexene amino ester, is an analgetic.

Item Type: Article
Subjects: Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
Depositing User: Dr Loránd Kiss
Date Deposited: 25 Sep 2014 10:46
Last Modified: 03 Dec 2014 01:15

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