Synthesis of Carbocyclic and Heterocyclic β‑Aminocarboxylic Acids

Kiss, Lorand and Fülöp, Ferenc (2014) Synthesis of Carbocyclic and Heterocyclic β‑Aminocarboxylic Acids. Chemical Review, 114. pp. 1116-1169.

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Abstract

In consequence of their biological e ff ects, conformationally constrained carbocyclic β -amino acids have generated great interest among synthetic and medicinal chemists in the past 2 decades, and they have become a hot topic in organic and bioorganic chemistry. These compounds are found in natural products and antibiotics. They are also considered important precursors for pharmacologically interesting β -lactams and other bioactive compounds. Certain carbocyclic β -amino acids, e.g., cispentacin , icofungipen , and BAY Y9379 , possess noteworthy antifungal or antibacterial activities, while tilidin , a phenyl-substituted cyclohexene amino ester, is an analgetic.

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