Carbotrifluoromethylations of C–C Multiple Bonds (Excluding Aryl‐ and Alkynyltrifluoromethylations)

Aradi, Klára and Kiss, Loránd (2023) Carbotrifluoromethylations of C–C Multiple Bonds (Excluding Aryl‐ and Alkynyltrifluoromethylations). CHEMISTRY-A EUROPEAN JOURNAL, 29 (19). No-e202203499. ISSN 0947-6539

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Abstract

Organofluorine chemistry has become an expanding area of research in organic chemistry and drug design. The synthesis of fluorine-containing molecules has received high significance in synthetic chemistry. Trifluoromethylative difunctionalizations of carbon?carbon multiple bonds with the simultaneous introduction of a CF3 group and another function have considerable relevance. Because of the high importance of carbon?carbon bond-forming reactions in organic synthesis, carbotrifluoromethylations are considered to be a field of synthetic chemistry of increasing importance. Our current goal in this review is to summarize recent developments of various trifluoromethylation reactions (excluding aryl- and alkynyl-trifluoromethylations) taking into consideration several main approaches, such as alkenyltrifluoromethylation, alkyltrifluoromethylation, carbonyltrifluoromethylation, and cyanotrifluoromethylation reactions.

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