Effective temperature of mutations.

Derényi, Imre and Szöllősi, Gergely J (2015) Effective temperature of mutations. Physical review letters, 114 (5). 058101. ISSN 1079-7114


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Biological macromolecules experience two seemingly very different types of noise acting on different time scales: (i) point mutations corresponding to changes in molecular sequence and (ii) thermal fluctuations. Examining the secondary structures of a large number of microRNA precursor sequences and model lattice proteins, we show that the effects of single point mutations are statistically indistinguishable from those of an increase in temperature by a few tens of kelvins. The existence of such an effective mutational temperature establishes a quantitative connection between robustness to genetic (mutational) and environmental (thermal) perturbations.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Depositing User: Dr Gergely J Szöllősi
Date Deposited: 28 Sep 2015 09:19
Last Modified: 28 Sep 2015 09:19

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