Peptide epitopes: Identification and structural modifications of synthetic antigens

Uray, Katalin and Hudecz, Ferenc (2015) Peptide epitopes: Identification and structural modifications of synthetic antigens. In: Amino Acids, Peptides and Proteins. The Royal Society of Chemistry, Cambridge, UK, pp. 68-113. ISBN 978-1-84973-982-5

Text UK_HF_68-113.pdf - Published Version Restricted to Repository staff only Download (1MB) | Request a copy

Abstract

The application of MoAbs (and their fragments), the use of various constructs containing synthetic epitope peptides and of recombinant fusion proteins with inserted epitope sequence in understanding fundamental biological (e.g. immune) processes, in diagnosis and/or treatment of various diseases (e.g. cancer, infectious and autoimmune diseases) is on the rise. The objective of this chapter is to review recent achievements in identification and structural manipulation of peptide epitopes (named also as antigenic determinants, peptide antigens/ immunogens) derived from proteins and also to outline the use of these compounds for various applications like analysis of relevant intermolecular interactions, development of novel reagents, biologicals (e.g. monoclonal or polyclonal antibodies and their drug conjugates), target antigens for diagnostics, treatment and/or of vaccines for biomedical research.

Actions (login required)

Edit Item