REAL

Magnetic iron oxide nanoparticles as MRI contrast agents - a comprehensive physical and theoretical study

Taukulis, R. and Widdrat, M. and Kumari, M. and Heinke, D. and Rumpler, M. and Tompa, É. and Uebe, R. and Kraupner, A. and Cebers, A. and Schüler, D. and Pósfai, M. and Hirt, A.M. and Faivre, D. (2015) Magnetic iron oxide nanoparticles as MRI contrast agents - a comprehensive physical and theoretical study. Magnetohydrodynamics, 51 (4). pp. 721-747. ISSN 0024-998X

[img]
Preview
Text
PM_TE_magnetic_iron_oxide_nanoparticles_as_MRI_contrast_agents_Magnetohydrodynamics_2015.pdf

Download (11MB) | Preview

Abstract

Magnetite nanoparticles, especially superparamagnetic iron oxide nanoparticles, are established contrast agents for magnetic resonance imaging. Magnetosomes, which are magnetite nanoparticles of biological origin, have been shown to have better contrast properties than current formulations possibly because of their larger size and high monodispersity. Here, we present an integrated study of magnetosomes and synthetic magnetite nanoparticles of varying size, hence, magnetic properties. We investigate not only the relaxation times as a measure for the contrast properties of these particles, but also their cytotoxicity and demonstrate the higher contrast of the larger particles. A theoretical model is presented that enables us to simulate the R2=R1 ratio of a contrast agent and con�rm that larger particles offer higher contrast. The results from this study illustrate the possibility to obtain colloidal stability of large magnetic nanoparticles for magnetic resonance imaging applications and serve as an impetus for a more quantitative description of the contrast effect as a function of the size.

Item Type: Article
Subjects: Q Science / természettudomány > QE Geology / földtudományok
Q Science / természettudomány > QE Geology / földtudományok > QE02 Geochemistry / geokémia
Depositing User: Angelina Hofstedterné Jutasi
Date Deposited: 10 Mar 2016 09:35
Last Modified: 10 Mar 2016 09:35
URI: http://real.mtak.hu/id/eprint/34358

Actions (login required)

Edit Item Edit Item