Sváb, Domonkos and Bálint, Balázs and Maróti, Gergely and Tóth, István
(2016)
Cytolethal distending toxin producing Escherichia coli O157:H43 strain
T22 represents a novel evolutionary lineage within the O157 serogroup.
INFECTION GENETICS AND EVOLUTION, 46.
pp. 110-117.
ISSN 1567-1348
Abstract
Enterohemorrhagic Escherichia coli (EHEC) O157:H7/NMstrains are significant foodborne pathogens intensively
studied, while other sero- and pathotypes of the O157 serogroup only began to receive more attention. Here we
report the first genome sequence of a cytolethal distending toxin (CDT-V) producing E. coli O157:H43 strain
(T22) isolated from cattle. The genome consists of a 4.9 Mb chromosome assembled into three contigs and one
plasmid of 82.4 kb. Comparative genomic investigations conducted with the core genomes of representative E.
coli strains in GenBank (n = 62) confirmed the separation of T22 from the EHEC and enteropathogenic (EPEC)
O157 lineages. Gene content based pangenome analysis revealed as many as 261 T22-specific coding sequences
without orthologs in EDL933 EHEC O157 prototypic and two phylogenetically related commensal E. coli strains.
The genome sequence revealed 10 prophage-like regions which harbor several virulence-associated genes including
cdt and heat-labile enterotoxin (LT-II) encoding operons. Our results indicate that the evolutionary
path of T22 is largely independent from that of EHEC and EPEC O157:H7/NM strains. Thus, the CDT-producing
T22 E. coli O157:H43 strain represents a unique lineage of E. coli O157.
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Cytolethal distending toxin producing Escherichia coli O157:H43 strain
T22 represents a novel evolutionary lineage within the O157 serogroup. (deposited 11 Jan 2017 19:10)
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