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The clear and dark sides of water: influence on the coiled coil folding domain

Vajda, Tamás and Perczel, András (2016) The clear and dark sides of water: influence on the coiled coil folding domain. Biomolecular Concepts, 7 (3). pp. 189-195. ISSN 1868-503X

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Abstract

Abstract: The essential role of water in extra- and intra- cellular coiled coil structures of proteins is critically evaluated, and the different protein types incorporating coiled coil units are overviewed. The following subjects are discussed: i) influence of water on the formation and degradation of the coiled coil domain together with the stability of this conformer type; ii) the water’s paradox iii) design of coiled coil motifs and iv) expert opinion and outlook is presented. The clear and dark sides refer to the positive and negative aspects of the water molecule, as it may enhance or inhibit a given folding event. This duplic- ity can be symbolized by the Roman ‘Janus-face’ which means that water may facilitate and stimulate coiled coil structure formation, however, it may contribute to the fatal processes of oligomerization and amyloidosis of the very same polypeptide chain.

Item Type: Article
Subjects: Q Science / természettudomány > QD Chemistry / kémia
Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
Depositing User: Dóra K. Menyhárd
Date Deposited: 07 Feb 2017 14:22
Last Modified: 07 Feb 2017 14:22
URI: http://real.mtak.hu/id/eprint/47621

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