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Investigation of drug distribution in tablets using surface enhanced Raman chemical imaging

Firkala, Tamás and Farkas, Attila and Vajna, Balázs and Farkas, István and Marosi, György (2013) Investigation of drug distribution in tablets using surface enhanced Raman chemical imaging. Journal of Pharmaceutical and Biomedical Analysis, 76. pp. 145-151. ISSN 0731-7085

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Abstract

This paper reports the first application of surface enhanced Raman chemical imaging on pharmaceutical tablets containing the active ingredient (API) in very low concentrations.Taking advantage of the extremely intensive Raman signals in the presence of silver colloids,image aquisition time was radically decreased. Moreover, the investigation of drug distribution below the detection limit of regular micro-Raman spectrometry was made feasible. The characteristics of different manufacturing technologies could be revealed at very low API concentrations by using chemometric methods for processing and evaluating the large number of varying spectra provided with this imaging method.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QD Chemistry / kémia
Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia
Depositing User: Dr. xAranka xPilbáth
Date Deposited: 08 May 2013 11:03
Last Modified: 08 May 2013 11:03
URI: http://real.mtak.hu/id/eprint/5065

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