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Potential Benefits of Discrete-Time Controllerbased Treatments over Protocol-based Cancer Therapies

Sápi, Johanna and Drexler, Dániel András and Kovács, Levente (2017) Potential Benefits of Discrete-Time Controllerbased Treatments over Protocol-based Cancer Therapies. ACTA POLYTECHNICA HUNGARICA, 14 (1). pp. 11-23. ISSN 1785-8860

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Abstract

In medical practice, the effectiveness of fighting cancer is not only determined by the composition of the used drug, but determ ined by the administration method as well. As a result, having drugs with a suitable action profile is just a promising beginning, but without appropriate delivery method s , the therapy still can be ineffective. Finding the optimal biologic dose is an empir ical process in medical practice; however, using controllers, an automated optimal administration can be determined . In this paper , we evaluate the effectiveness of different drug delivery protocols; using in silico simulations (like bolus dose s, low - dose metron omic regimen and continuous infusion therapy ). In addition, we compare these results with discrete - time controller - based treatments containing state feedback, setpoint control, actual state observer and load estimation.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 30 May 2017 06:27
Last Modified: 30 May 2017 06:27
URI: http://real.mtak.hu/id/eprint/54163

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