Potential Benefits of Discrete-Time Controllerbased Treatments over Protocol-based Cancer Therapies

Sápi, Johanna and Drexler, Dániel András and Kovács, Levente (2017) Potential Benefits of Discrete-Time Controllerbased Treatments over Protocol-based Cancer Therapies. ACTA POLYTECHNICA HUNGARICA, 14 (1). pp. 11-23. ISSN 1785-8860

Preview

Text Sapi_Drexler_Kovacs_72.pdf Download (490kB) | Preview

Abstract

In medical practice, the effectiveness of fighting cancer is not only determined by the composition of the used drug, but determ ined by the administration method as well. As a result, having drugs with a suitable action profile is just a promising beginning, but without appropriate delivery method s , the therapy still can be ineffective. Finding the optimal biologic dose is an empir ical process in medical practice; however, using controllers, an automated optimal administration can be determined . In this paper , we evaluate the effectiveness of different drug delivery protocols; using in silico simulations (like bolus dose s, low - dose metron omic regimen and continuous infusion therapy ). In addition, we compare these results with discrete - time controller - based treatments containing state feedback, setpoint control, actual state observer and load estimation.

Actions (login required)

Edit Item