Proteomic and Glycomic Markers to Differentiate Lung Adenocarcinoma from COPD

Szabó, Miklós and Hajba, László and Kun, Renáta and Guttman, András and Csánky, Eszter (2018) Proteomic and Glycomic Markers to Differentiate Lung Adenocarcinoma from COPD. Current Medicinal Chemistry, 25. ISSN 0929-8673 (In Press)

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Abstract

Lung adenocarcinoma is one of the leading causes of mortality among cancer patients worldwide and chronic obstructive pulmonary disease (COPD) is also high in death statistics. In addition, patients with chronic obstructive pulmonary disease (COPD) have high risk for developing primary lung cancer. Prevention, risk estimation and a non-invasive diagnostics are essential to decrease COPD and lung cancer mortality. Therefore, better and more accurate molecular diagnostic markers (biomarkers) are needed for the early differential diagnosis of these lung diseases to help clinicians making better therapeutic decisions. This review is focusing on recently discovered adenocarcinoma and COPD biomarkers at the proteome and glycome level. In the first part the protein markers are summarized, while the second part is focused on glycan markers. Their use to differentiate between chronic inflammation (COPD) and malignant (adenocarcinoma) diseases are discussed in detail.

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