REAL

Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage.

Aradi, Mihaly and Koszegi, Edit and Orsi, Gergely and Perlaki, Gabor and Trauninger, Anita and Toth, Arnold and Schwarcz, Attila and Illes, Zsolt (2013) Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage. European neurology, 69 (4). pp. 221-5. ISSN 1421-9913

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Abstract

BACKGROUND The long-term effect of neuromyelitis optica (NMO) on the brain is not well established. METHODS After 22 years of NMO, a patient's brain was examined by quantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short-term NMO and 20 healthy subjects. RESULTS Although routine T1- and T2-weighted images appeared to be normal, quantitative T1-, T2- and diffusion-weighted magnetic resonance imaging identified areas with high diffusivity and altered relaxation time in 'normal appearing white matter' (NAWM). In such abnormal NAWM regions, biexponential diffusion analysis and quantitative spectroscopy indicated extracellular edema and axonal loss, respectively. Repeated analysis 6 months later identified the same alterations. Such patchy alterations were not detectable in the NAWM of the 3 cases with short-term NMO, and they were also not quantitatively different from the controls. CONCLUSION After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Dr. Endre Czeiter
Date Deposited: 07 Feb 2014 06:51
Last Modified: 07 Feb 2014 06:51
URI: http://real.mtak.hu/id/eprint/10138

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