Kelemen, Lóránd and Lepera, E. and Horváth, B. and Ormos, Pál and Osellame, R. and Martínez Vázquez, R. (2019) Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing. Lab on a Chip, 19 (11). pp. 1985-1990. ISSN 1473-0197
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Abstract
Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin-streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 x 10(3) molecules per mu m(2).
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3020 Biophysics / biofizika |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 21 Nov 2019 19:58 |
Last Modified: | 21 Jan 2020 00:15 |
URI: | http://real.mtak.hu/id/eprint/103546 |
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