ELM-the eukaryotic linear motif resource in 2020

Kumar, Manjeet and Gouw, Marc and Michael, Sushama and Samano-Sanchez, Hugo and Pancsa, Rita and Glavina, Juliana and Diakogianni, Athina and Alvarado Valverde, Jesús and Bukirova, Dayana and Calyseva, Jelena and Palopoli, Nicolas and Davey, Norman E. and Chemes, Lucía B. and Gibson, Toby J. (2019) ELM-the eukaryotic linear motif resource in 2020. NUCLEIC ACIDS RESEARCH. ISSN 0305-1048

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Abstract

The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications. ELM is available at: http://elm.eu.org.

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