Bulk and surface sensitivity of a resonant waveguide grating imager

Orgovan, Norbert and Kovács, Boglárka and Farkas, Enikő and Szabó, Bálint and Horváth, Róbert (2014) Bulk and surface sensitivity of a resonant waveguide grating imager. APPLIED PHYSICS LETTERS, 104. pp. 1-5. ISSN 0003-6951

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Abstract

We report the assessment of the sensitivity of a microplate-compatible resonant waveguide grating imager. The sensitivity to bulk refractive index changes was determined using a serial dilution of glycerol solution with the help of a refractometer. The surface sensitivity was examined using layer-by-layer polyelectrolyte films in conjunction with optical waveguide lightmode spectroscopy and characterized by the binding of acetazolamide to immobilized carbonic anhydrase under microfluidics. The results suggest that the imager has a limit of detection down to 2.2 × 10−6 for refractive index change and 0.078 ng/cm2 for the adsorbed mass. © 2014 AIP Publishing LLC

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