Fluorine-containing drugs approved by the FDA in 2019

Haibo, Mei and Remete, Attila Márió and Yupiao, Zou and Moriwaki, Hiroki and Fustero, Santos and Kiss, Loránd and Soloshonok, Vadim A. and Jianlin, Han (2020) Fluorine-containing drugs approved by the FDA in 2019. CHINESE CHEMICAL LETTERS, 31. pp. 2401-2413. ISSN 1001-8417

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Abstract

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed. Therapeutic areas include schizophrenia, migraine, multiple sclerosis, insomnia, rheumatoid arthritis, anti-tuberculosis, breast cancer, lymphoma kinase inhibitor, serotonin receptor antagonist. New pharmaceuticals feature four examples of aromatic fluorine, three aromatic CF3 group, three aliphatic CF3 and one compound with aromatic CF3O group. Furthermore, among the new compounds, six are chiral and seven are derived from tailor-made amino acids

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