Compartmentalized dendritic plasticity during associative learning

d'Aquin, Simon and Szőnyi, András and Mahn, Mathias and Krabbe, Sabine and Gruendemann, Jan (2022) Compartmentalized dendritic plasticity during associative learning. SCIENCE, 376 (6590). 266-+. ISSN 0036-8075

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Abstract

Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. Activity-dependent plasticity of synaptic input is a major underlying cellular process. Although we have a detailed understanding of synaptic and dendritic plasticity in vitro, little is known about the functional and plastic properties of active dendrites in behaving animals. Using deep brain two-photon Ca2+ imaging, we investigated how sensory responses in amygdala principal neurons develop upon classical fear conditioning, a form of associative learning. Fear conditioning induced differential plasticity in dendrites and somas regulated by compartment-specific inhibition. Our results indicate that learning-induced plasticity can be uncoupled between soma and dendrites, reflecting distinct synaptic and microcircuit-level mechanisms that increase the computational capacity of amygdala circuits.

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