White matter abnormalities : Insights into the pathophysiology of major affective disorders

Serafini, Gianluca and Gonda, Xénia and Rihmer, Zoltán and Girardi, Paolo and Amore, Mario (2014) White matter abnormalities : Insights into the pathophysiology of major affective disorders. World Journal of Radiology, 6 (6). pp. 223-229. ISSN 1949-8470, ESSN: 1949-8470

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Abstract

Abstract The presence of white matter hyperintensities (WMHs) has been commonly associated with poor outcome in subjects with major affective disorders. Unfortunately, WMHs may be frequently confounded by the use of psychoactive medications and duration of illness. Although findings from the current literature are quite conflicting, we proposed that subjects with WMHs may be at higher suicidal risk when compared to other subgroups without. Based on the Fazekas modified scale, the severity of WMHs may serve as a trait marker of disease. Interestingly, the presence of WMHs may represent a neurobiological marker between the underlying vulnerability and clinical presentation of major affective disorders.

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