Bahar, Mehmet Refik and Tekin, Suat and Beytur, Asiye and Onalan, Ebru Etem and Ozyalin, Fatma and Colak, Cemil and Sandal, Süleyman (2023) Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins. BIOLOGIA FUTURA, 74 (1-2). pp. 159-170. ISSN 2676-8615 (print); 2676-8607 (online)
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Abstract
This study was conducted to determine the possible effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins (UCPs) in rats. Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 μM MOTS-c. Hypothalamus, blood, muscle, adipose tissues samples were collected for thyrotropin-releasing hormone (TRH), UCP1 and UCP3 levels were determined by the RT-PCR and western blot analysis. Serum thyroid hormone levels were determined by the ELISA assays. MOTS-c infusion was found to increase food con- sumption but it did not cause any changes in the body weight. MOTS-c decreased serum TSH, T3, and T4 hormone levels. On the other hand, it was also found that MOTS-c administration increased UCP1 and UCP3 levels in peripheral tissues. The findings obtained in the study show that central MOTS-c infusion is a directly effective agent in energy metabolism.
Item Type: | Article |
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Uncontrolled Keywords: | MOTS-c, Thyroid hormones, Energy use, UCP1, UCP3 |
Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia |
Depositing User: | Beáta Bavalicsné Kerekes |
Date Deposited: | 05 Sep 2023 07:29 |
Last Modified: | 05 Sep 2023 07:29 |
URI: | http://real.mtak.hu/id/eprint/172664 |
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