Kristóf, Zsüliet and Gál, Zsófia and Török, Dóra and Eszlári, Nóra and Sütöri, Sára and Erdélyi-Hamza, Berta and Petschner, Péter and Sperlágh, Beáta and Bagdy, György and Juhász, Gabriella and Gonda, Xénia (2023) Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation. SCIENTIFIC REPORTS, 13 (1). ISSN 2045-2322
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VariationalongP2RX7interactswithearlytraumasonseverityofanxietysuggestingaroleforneuroinflammation.pdf Download (2MB) | Preview |
Abstract
Emotional stress is a leading risk factor in the development of neuropsychiatric disorders possibly via immune activation. P2X7 receptors promote neuroinflammation, and research suggests a relationship between chromosome region 12q2431, in which the P2X7R gene is located, and development of mood disorders, however, few studies concentrate on its association with anxiety. Our aim was to investigate the effects of P2RX7 variation in interaction with early childhood traumas and recent stressors on anxiety. 1752 participants completed questionnaires assessing childhood adversities and recent negative life events, provided data on anxiety using the Brief Symptom Inventory, and were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into linear regression models followed by a linkage disequilibrium-based clumping procedure to identify clumps of SNPs with a significant main or interaction effect. We identified a significant clump with top SNP rs67881993 and containing a set of 29SNPs that are in high LD, which significantly interacted with early childhood traumas but not with recent stress conveying a protective effect against increased anxiety in those exposed to early adversities. Our study demonstrated that P2RX7 variants interact with distal and more etiological stressors in influencing the severity of anxiety symptoms, supporting previous scarce results and demonstrating its role in moderating the effects of stress.
| Item Type: | Article |
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| Additional Information: | Doctoral School of Mental Health Sciences, Semmelweis University, Budapest, Hungary Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary Department of Psychiatry and Psychotherapy, Semmelweis University, Gyulai Pál Str. 2, Budapest, 1085, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Bioinformatics Center, Institute of Chemical Research, Kyoto University, Uji, Kyoto, Japan Research Unit for Realization of Sustainable Society, Kyoto University, Uji, Kyoto, Japan Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom Export Date: 8 January 2024 Correspondence Address: Gonda, X.; Department of Psychiatry and Psychotherapy, Gyulai Pál Str. 2, Hungary; email: gonda.xenia@semmelweis.hu |
| Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 12 Jan 2024 08:21 |
| Last Modified: | 12 Jan 2024 08:21 |
| URI: | http://real.mtak.hu/id/eprint/184492 |
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