Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization.

Bódis, József and Peti, AM. and Sulyok, Endre and Kovács L., Gábor and Várnagy, Ákos (2014) Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 59 (9). pp. 1313-1318. ISSN 1434-6621

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Abstract

Abstract Backgrounds: This case-control study was designed to assess the possible role of fetuin-A, a multifunctional protein, in reproductive processes of women undergoing in vitro fertilization (IVF). Methods: Paired serum and follicular fluid (FF) samples were obtained from 35 unselected patients who received IVF treatment. Their main clinical chartacteristics: age 35.2+/-5.4 years, BMI 22.9+/-2.8, duration of infertility 3.2+/-2.0 years, gonadotropin administered 1199.4+/-202.3 IU, and estradiol level on day 6 of stimulation 1827+/-1342 pmol/L. In total 25 healthy women of similar age admitted for minor elective surgery served as controls for serum analysis. Fetuin-A and high-sensitivity C-reactive protein (hsCRP) were measured in serum and FF by using commercially available ELISA kits and turbidimetric immunoassay, respectively. Results: Serum fetuin-A levels of patients participating IVF are markedly elevated when compared to those of healthy women (1.30+/-0.58 g/L vs. 0.55+/-0.09 g/L, p<0.000). Fetuin-A in FF proved to be comparable to its serum levels (1.17+/-0.45 g/L) and no relationship could be detected between the respective individual values. Moreover, markers of reproductive potential (number of oocytes and embryos) appeared to be independent of serum and FF fetuin-A. hsCRP in serum and FF was not related to fetuin-A and did not influence the number of oocytes and embryos. Conclusions: Fetuin-A concentration is high in FF of patients undergoing IVF, however, it can not be used as an estimate of fertilization success.

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