Synthesis and study of new paramagnetic resveratrol analogues

Kálai, Tamás and Borza, Erzsébet and Antus, Csenge and Radnai, Balázs and Gulyás-Fekete, Gergely and Fehér, Andrea and Sümegi, Balázs and Hideg, Kálmán (2011) Synthesis and study of new paramagnetic resveratrol analogues. Bioorganic and Medicinal Chemistry, 19 (24). pp. 7311-7317.

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Abstract

New resveratrol analogues containing five- and six-membered nitroxides and isoindoline nitroxides were synthesized. These new compounds were compared to resveratrol based on their ABTS radical scavenging ability as well on their capacity to suppress inflammatory process in macrophages induced by lipopolysaccharides. The ABTS and ROS scavenging activities of new molecules were the same or weaker than that of resveratrol, but some of paramagnetic resveratrol derivatives suppressed nitrite and TNFa production more efficiently than resveratrol. Based on these results the new nitroxide and phenol containing hybrid molecules can be considered as new antioxidant and anti-inflammatory agents.

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