The modulatory effect of estrogen on the neuronal activity in the barrel cortex of the rat. An electrophysiological study

Kis, Zsolt and Budai, Dénes and Imre, Gábor and Farkas, Tamás and Horváth, Szatmár and Toldi, József (2001) The modulatory effect of estrogen on the neuronal activity in the barrel cortex of the rat. An electrophysiological study. NeuroReport, 12 (11). pp. 2509-2512. ISSN 0959-4965 (print), 1473-558X (online)

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Abstract

In acute experiments, the effects of iontophoretically applied 17 beta -estradiol hemisuccinate on the activity of the primary somatosensory cortical neurons were studied in ovariectomized rats by extracellular single-unit recording. 17 beta -Estradiol increased both the spontaneous and the vibrissa deflection-evoked responses, with an average latency of 24 min. It is suggested that this relatively long latency of the 17 beta -estradiol effect is based not so much on membrane mechanisms as on genomic mechanisms

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