Surprising sequential effects on MMN

Frost, J.D. and Winkler, István and Provost, Alexander and Todd, Juanita (2016) Surprising sequential effects on MMN. Biological Psychology, 116. pp. 47-56. ISSN 0301-0511

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Abstract

The mismatch negativity (MMN) is conceptualised as a confidence-weighted error signal elicited when a deviation violates the predicted next-state based on regularity. The mechanisms underpinning its generation remain contentious. Smaller MMN response is a robust finding in schizophrenia and reduced amplitude may implicate impairment in prediction-error signalling. An enriched understanding of factors that influence MMN size in healthy people is a prerequisite for translating the relevance of reduced MMN in schizophrenia. This paper features two studies designed to explore factors that impact MMN in healthy individuals. Study 1 confirms that MMN amplitude does not faithfully reflect transition statistics and is susceptible to order-driven bias. In Study 2, we demonstrate that an order-driven bias remains despite repeated encounters with sound sequences. These data demonstrate that factors that impact on MMN size in non-clinical groups are not fully understood and that some mechanisms driving relevance filtering are likely influenced by ‘top-down’ expectations.

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