Domoki, Ferenc and Sántha, Péter and Bari, Ferenc and Jancsó, Gábor (2003) Perineural capsaicin treatment attenuates reactive hyperaemia in the rat skin. Neuroscience Letters, 341 (2). pp. 127-130. ISSN 0304-3940
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Abstract
The neural mechanisms of reactive cutaneous hyperaemia were studied by using a novel experimental approach: the simultaneous measurement of cutaneous blood flow by laser-Doppler flowmetry in adjacent innervated and chemodenervated skin regions of the rat hindpaw served by the same artery. Transient occlusion of the femoral artery (0.5-6 min) resulted in reactive hyperaemia that was greatly reduced in the chemodenervated region. After 3 min arterial occlusion, peak cutaneous blood flow was 109 +/- 13% vs. 53 +/- 7%* (% change from baseline, n = 11, *P < 0.05), and the total hyperaemic response was 110 +/- 21 vs. 52 +/- 12* (arbitrary perfusion units) in intact vs. chemodenervated skin regions, respectively. The findings provide clear evidence for the involvement of peptidergic capsaicin-sensitive afferent nerves in the mechanism of reactive cutaneous hyperaemia.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia Q Science / természettudomány > QP Physiology / élettan R Medicine / orvostudomány > RZ Other systems of medicine / orvostudomány egyéb területei |
Depositing User: | Erika Bilicsi |
Date Deposited: | 18 Dec 2012 13:10 |
Last Modified: | 18 Dec 2012 13:10 |
URI: | http://real.mtak.hu/id/eprint/3620 |
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