ASYMMETRIC REDUCTION OF KETONES TO CHIRAL PLATFORM MOLECULES

Fridrich, Bálint and Tukacs, József M. and Mika, László Tamás (2016) ASYMMETRIC REDUCTION OF KETONES TO CHIRAL PLATFORM MOLECULES. In: ADVANCES IN ASYMMETRIC AUTOCATALYSIS AND RELATED TOPIC. Elsevier. (In Press)

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Abstract

The enantioselective reduction of prochiral substrates including C=O double bonds is fundamentally important in the synthesis of biologically active compounds. Due to the depletion of fossil-based resources, the production of these species from renewable resources is highly desired. The enantiopure γ-valerolactone was proposed as a biomass-based chiral platform molecule that can be easily obtained by the asymmetric reduction of levulinic acid and its esters. Synthetic schemes of the production of optically active γ-valerolactone are presented. The effect of catalyst composition and reaction parameters on the activity and selectivity will be discussed in detail.

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