The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients

Szamosi, Tamás and Lakatos, Péter László and Szilvási, Anikó and Lakatos, László and Kovacs, Agota and Molnár, Tamás and Altorjay, István and Papp, Mária and Szabo, Orsolya and Satori, Anna and Tulassay, Zsolt and Miheller, Pál and Horváth, Henrik Csaba and Papp, János and Tordai, Attila and Andrikovics, Hajnalka (2009) The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients. Digestive Diseases and Sciences, 54 (2). pp. 351-359. ISSN 0163-2116 (print), 1573-2568 (online)

Text 1123248.pdf Restricted to Registered users only Download (239kB) | Request a copy

Abstract

Purpose In previous studies the NFKBIA 3'alleles did not predict response to medical therapy or need for surgery.UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/del-ATTG mutation increased the risk for ulcerative colitis (UC). The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or disease phenotype in Hungarian inflammatory bowel disease (IBD) patients. Methods NFKBIA 3'UTR- and NFKB1-94ins/delATTG polymorphisms were investigated in 415 unrelated IBD patients (CD: 266 patients, mean age 35.2 +/- 12.1 years, duration 8.7 +/- 7.5 years; UC patients: 149, mean age 44.4 +/- 15.4 years, duration 10.7 +/- 8.9 years) and 149 controls by PCR-restriction fragment length polymorphism (RFLP) analysis. Detailed clinical phenotypes were determined by reviewing the medical charts. Results The NFKBIA 3'UTR and NFKB1-94ins/ delATTG genotypes and allele frequencies were not significantly different among IBD and controls. In patients with UC, the 3'UTR GG genotype was associated with extensive colitis (55.3 vs. 29.4%, odds ratio 2.97, 95% confidence interval 1.45-6.08). The presence of variant alleles did not predict response to steroids, infliximab, or need for surgery. Conclusions The NFKBIA 3'UTR GG genotype was associated with an increased risk for extensive colitis in Hungarian patients. In contrast, variant alleles did not predict response to medical therapy or need for surgery.

Actions (login required)

Edit Item