Survivin promoter polymorphism and cervical carcinogenesis

Borbély, A. A. and Murvai, Melinda and Szarka, Krisztina Zsuzsanna and Kónya, József and Gergely, Lajos and Hernádi, Zoltán and Veress, György (2006) Survivin promoter polymorphism and cervical carcinogenesis. Journal of Clinical Pathology, 60 (3). pp. 303-306. ISSN 0021-9746

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Abstract

Background: Survivin, a novel member of the inhibitor of apoptosis family, plays an important role in cell cycle regulation. A common polymorphism at the survivin gene promoter (G/C at position 31) was shown to be correlated with survivin gene expression in cancer cell lines. Aim: To investigate whether this polymorphism could be involved in the development of human papillomavirus (HPV)-associated cervical carcinoma. Methods: Survivin promoter polymorphism was detected in patients with cervical cancer, in patients with equivocal cytological atypia and in a control population using polymerase chain reaction (PCR-restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism analysis. HPV was typed in patients with cervical cancer and cytological atypia using PCR-RFLP. Results: No statistically significant differences were found in the genotype distributions of the survivin promoter variants among our study groups. Conclusions: The survivin promoter polymorphism at position 31 may not represent an increased risk for the development of cervical cancer, at least in the population studied here.

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