Phytoestrogens alter cortisol and and rostenedione secretion by porcine adrenocortical cells

Kamińska, Barbara and Opalka, M. and Dusza, Luiza (2007) Phytoestrogens alter cortisol and and rostenedione secretion by porcine adrenocortical cells. Acta Veterinaria Hungarica, 55 (3). pp. 359-367. ISSN 0236-6290

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Abstract

The effect of plant-derived, nonsteroidal estrogens (genistein, daidzein and biochanin A) on cortisol and androstenedione secretion by porcine adrenocortical cells was examined. Adrenals were harvested from locally slaughtered mature gilts on days 5–9 of the oestrous cycle. Adrenocortical cells were incubated with or without genistein, daidzein, biochanin A (0.5, 5, 10 or 50 μM), oestradiol (10, 50, 100 or 500 pg/mL) and ACTH (5 nM — positive control). All incubations were performed for 8 h (95% air and 5% CO ₂ , 37°C). ACTH increased cortisol and androstenedione secretion. Genistein, daidzein and biochanin A suppressed cortisol output, whereas androstenedione secretion was enhanced by these phytoestrogens. In contrast, oestradiol did not alter steroid secretion by porcine adrenocortical cells, which may suggest that phytoestrogens have a non-oestrogenic mechanism of action. Therefore, phytoestrogens present in commercial forage may influence adrenocortical function in pigs by decreasing cortisol and increasing androstenedione secretion.

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