Anti-chlamydial effect of plant peptides

Balogh, Emese and Mosolygó, Tímea and Tiricz, Hilda and Szabó, Ágnes and Karai, Adrienn and Kerekes, Fanni and Virók, Dezső and Kondorosi, Éva and Burián, Katalin (2014) Anti-chlamydial effect of plant peptides. Acta Microbiologica et Immunologica Hungarica, 61 (2). pp. 229-239. ISSN 1217-8950

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Abstract

Even in asymptomatic cases of Chlamydia trachomatis infection, the aim of the antibiotic strategy is eradication of the pathogen so as to avoid the severe late sequelae, such as pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. Although first-line antimicrobial agents have been demonstrated to be predominantly successful in the treatment of C. trachomatis infection, treatment failures have been observed in some cases. Rich source of antimicrobial peptides was recently discovered in Medicago species, which act in plants as differentiation factors of the endosymbiotic bacterium partner. Several of these symbiotic plant peptides have proved to be potent killers of various bacteria in vitro. We show here that 7 of 11 peptides tested exhibited antimicrobial activity against C. trachomatis D, and that the killing activity of these peptides is most likely due to their interaction with specific bacterial targets.

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