Computational vaccinology and epitope vaccine design by immunoinformatics

Khalili, Saeed and Jahangiri, Abolfazl and Borna, Hojat and Ahmadi Zanoos, Kobra and Amani, Jafar (2014) Computational vaccinology and epitope vaccine design by immunoinformatics. Acta Microbiologica et Immunologica Hungarica, 61 (3). pp. 285-307. ISSN 1217-8950

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Abstract

Human immune system includes variety of different cells and molecules correlating with other body systems. These instances complicate the analysis of the system; particularly in postgenomic era by introducing more amount of data, the complexity is increased and necessity of using computational approaches to process and interpret them is more tangible.Immunoinformatics as a subset of bioinformatics is a new approach with variety of tools and databases that facilitate analysis of enormous amount of immunologic data obtained from experimental researches. In addition to directing the insight regarding experiment selections, it helps new thesis design which was not feasible with conventional methods due to the complexity of data. Considering this features immunoinformatics appears to be one of the fields that accelerate the immunological research progression.In this study we discuss advances in genomics and vaccine design and their relevance to the development of effective vaccines furthermore several division of this field and available tools in each item are introduced.

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