Increased total scavenger capacity in rats fed corticosterone and cortisol on lipid-rich diet

Stark, J. and Tulassay, Zs and Lengyel, G. and Szombath, D. and Székács, B. and Ádler, I. and Marczell, I. and Nagy-Répas, P. and Dinya, E. and Rácz, K. and Békési, G. and Horváth, Iván (2013) Increased total scavenger capacity in rats fed corticosterone and cortisol on lipid-rich diet. Acta Physiologica Hungarica, 100 (1). pp. 84-88. ISSN 0231-424X

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Abstract

Background: In our earlier studies both corticosterone and cortisol had antioxidant effect in vitro. Objectives: Our aim was to clarify whether corticosterone and cortisol oral administration results in beneficial antioxidant changes in Sprague-Dawley adult male rats in vivo. Methods: Experimental animals were fed a lipid rich diet and treated with corticosterone or cortisol in the drinking fluid. Control group was fed only lipid rich diet with untreated drinking water. The untreated group was fed a normal diet with untreated water. Total scavenger capacity (TSC) was measured before and after 4 weeks of treatment in blood samples using a chemiluminometric assay. Results: Both corticosterone and cortisol treatment caused increased TSC. The control group and the untreated group showed no significant changes in TSC. Conclusion: Our results support the hypothesis that corticosterone and cortisol administration can improve the antioxidant status not only in vitro but also in vivo.

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