Targeting mitochondrial ATP-sensitive potassium channels - a novel approach to neuroprotection

Busija, D. W. and Lacza, Zsombor and Rajapakse, N. and Kiss, Béla and Bari, Ferenc and Domoki, Ferenc (2004) Targeting mitochondrial ATP-sensitive potassium channels - a novel approach to neuroprotection. BRAIN RESEARCH REVIEWS, 46 (3). pp. 282-294. ISSN 0165-0173

Text 1169719.pdf Restricted to Registered users only Download (329kB) | Request a copy

Abstract

Mitochondrial responses to ischemic stress play an important role in necrosis and apoptosis of brain cells. Recent studies using several different experimental preparations have shown that activation of ATP-sensitive potassium channels in mitochondria (mitoK(ATP) channels) is able to protect neurons and astroglia against injury and death. Thus, targeting of mitoK(ATP) channe s appears to be a novel approach to neuroprotection. However, little is known about the mechanisms involved. The purpose of this re Jew is to detail the current state of knowledge about this important, emerging area of investigation, and to provide suggestions for future studies.

Actions (login required)

Edit Item