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Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Mosaferi Ziaaldini, Mohammad and Koltai, Erika and Csende, Zsolt and Goto, Sataro and Boldogh, István and Radák, Zsolt (2015) Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats. EXPERIMENTAL GERONTOLOGY, 67. pp. 9-14. ISSN 0531-5565

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Abstract

Abstract Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.

Item Type: Article
Uncontrolled Keywords: FOLLISTATIN; MYOSTATIN; Reactive oxygen species; skeletal muscle; Aging; Exercise
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 06 Sep 2017 12:55
Last Modified: 06 Sep 2017 12:55
URI: http://real.mtak.hu/id/eprint/61643

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