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Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans

Emri, Tamás and Szilágyi, Melinda and Justyák, Anikó and Pócsi, István (2008) Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans. Acta Microbiologica et Immunologica Hungarica, 55 (2). pp. 111-117. ISSN 1217-8950

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Abstract

Extracellular proteinase production induced by carbon starvation was studied in a series of heterotrimeric G protein signaling pathway mutants of Aspergillus nidulans . All the mutants tested — including Δ fadA (G α ), ΔsfaD (G β ), ΔgpgA (G γ ) and ΔsfgA (regulator of FadA signaling) — showed an elevated proteinase production after glucose depletion. Our results strongly support the view that during growth, FadA/SfaD/GpgA G protein signaling inhibits proteinase production via both G α and G βγ subunits, and all conditions, which are not sufficient to support vegetative growth and, hence, inhibit this type of G protein signaling, elevate extracellular proteinase activities.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: xFruzsina xPataki
Date Deposited: 17 Sep 2017 06:22
Last Modified: 17 Sep 2017 06:22
URI: http://real.mtak.hu/id/eprint/62633

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